ML 141
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产品名称:ML 141CAS:71203-35-5别名：ML141;5-(4-甲氧基苯基)-1-(4-氨基磺酰基苯基)-3-苯基-2-吡唑啉英文名：ML 141
- 储存条件 2-8°C
- 溶解度 DMSO: soluble5mg/mL (warmed, clear solution)
- 颜色white to beige
- 生物活性ML141是Rho家族GTPase cdc42的一种有效的，选择性可逆非竞争性抑制剂，IC50为200 nM。
- 体外研究ML141 enhances the ability of TMX to suppress BLBC cell growth through both induction of cell death and suppression of cell division. ML141 also significantly protects neuroblastoma cells from metformin-induced apoptosis. Moreover, ML141 diminishes K. pneumoniae invasion in a dose-dependent manner.
- 体内研究In NOD/SCID mice bearing MDA-MB 231 derived tumors, ML141 (1 mg/day i.p.), via inhibition of Cdc42, enables TMX to suppress growth of MDA-MB 231 derived tumors. In addition, ML141 (10 mg/kg i.p.) enhances G-CSF-induced hematopoietic stem and progenitor cell mobilization in mice.
