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发布者：信康 浏览次数：
产品名称:N/ACAS:1052532-15-6别名：N-[[4-[(6-氯-3-吡啶基)甲氧基]-3-甲氧基苯基]甲基]-3,4-二甲氧基苯乙胺盐酸盐英文名：SBE 13 hydrochloride
- 储存条件 2-8°C
- 溶解度 DMSO: ≥17mg/mL
- 颜色white to tan
- 生物活性SBE 13 HCl是一种有效的选择性PLK1抑制剂，IC50为200 pM，选择性比 Aurora A 激酶, Plk2 和 Plk3高4000多倍。
- 体外研究SBE 13 decreases cell proliferation in various cancer cell lines, and causes a G2/M arrest followed by apoptosis. In primary cells, SBE 13 does not impair cell cycle and thus proliferation of primary cells. SBE13 in combination with Enzastaurin displays a synergistic reduction of cell proliferation and enhanced apoptosis induction in HCT116(p53-/-) cells.
