CW069
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产品名称:CW069CAS:1594094-64-0别名：(S)-2-(2-(BENZYLAMINO)-3-PHENYLPROPANAMIDO)-5-IODOBENZOICACID;5-碘-2-[[(2S)-1-氧代-3-苯基-2-[(苯基甲基)氨基]丙基]氨基]苯甲酸英文名：CW069
[] - 生物活性CW069 是一种变构选择性microtubule motor protein HSET抑制剂，IC50为75 μM, 其选择性显著高于KSP.
- 体外研究CW069 increases multipolar spindles in N1E-115 cells with supernumerary centrosomes without altering bipolar spindle morphology in normal human dermal fibroblast cells. CW069 inhibits growth in cancer N1E-115 cells with IC50 of 10 μM, but not in NHDF or primary human bone marrow cells.
- 特征Allosteric, HSET-selective inhibitor.
