PAC1
发布者：信康 浏览次数：
产品名称:PAC1CAS:315183-21-2别名：4-(苯基甲基)-1-哌嗪乙酸2-[[2-羟基-3-(2-烯丙-1-基)苯基]亚甲基]酰肼;PAC1(4-(苯基甲基)-1-哌嗪乙酸2-[[2-羟基-3-(2-烯丙-1-基)苯基]亚甲基]酰肼);PAC-110MG;PAC-1,一种酶原-3激活剂英文名：PAC1
- 密度 1.14
- 储存条件 Store at +4°C
- 溶解度 DMSO: ≥10mg/mL
- 颜色white
- 用途 PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 渭M and caspase 7= 4.5 渭M. The IC50 for apoptosis induction = 0.92 渭M. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues.
