SC-514
发布者：信康 浏览次数：
产品名称:SC-514CAS:354812-17-2别名：SC-514;GK01140;IKK-2抑制剂;4-氨基-[2,3']联噻吩-5-甲酰胺英文名：SC-514
- 熔点 209-211°C
- 储存条件 Store at +4°C
- 溶解度 DMSO: soluble10mg/mL, clear
- 颜色white to light brown
- 用途 A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 碌M for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 碌M). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.
