GW441756
发布者：信康 浏览次数：
产品名称:GW441756CAS:504433-23-2别名：1,3-二氢-3-[(1-甲基-1H-吲哚-3-基)亚甲基]-2H-吡咯并[3,2-B]吡啶-2-酮;3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-1H-PYRROLO[3,2-B]PYRIDIN-2-ONE;HYDROCHLORIDE英文名：GW441756
- 生物活性GW441756是一种有效的，选择性的TrkA抑制剂，IC50为2 nM，对c-Raf1和CDK2几乎没有抑制活性。
- 体外研究GW441756 can specifically block TrkA-induced cell death in a dose-dependent manner. GW441756 can block TrkA-mediated γH2AX production and apoptosis in TrkA-overexpressing cells.
