N/A
发布者：信康 浏览次数：
产品名称:N/ACAS:950455-15-9别名：N-[(3-氯苯基)甲基]-螺[哌啶-4,2'(1'H)-喹喔啉]-3'-胺英文名：Liproxstatin-1
[] - 生物活性Liproxstatin-1 是一种有效的 ferroptosis 抑制剂。
- 体外研究Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H2O2 (200 µM).
- 体内研究Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury.
