SRT2104 (GSK2245840)

发布者：信康浏览次数：

产品名称:SRT2104 (GSK2245840)

CAS:1093403-33-8

别名：4-甲基-N-[2-[3-(吗啉基甲基)咪唑并[2,1-B]噻唑-6-基]苯基]-2-(吡啶-3-基)噻唑-5-甲酰胺;SRT2104选择性SIRT1活化剂

英文名：SRT2104 (GSK2245840)

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生物活性SRT2104 (GSK2245840)是一种选择性 SIRT1 活化剂，参与能量平衡的调节。Phase 2。
体外研究SRT2104 reduces p65/RelA acetylation levels in C2C12 cells.
体内研究In male C57BL/6J mice, SRT2104 (100 mg/kg, p.o.) extends both mean and maximal lifespan of mice fed a standard diet, and enhances motor coordination, bone mineral density, and insulin sensitivity and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle mass in an experimental model of atrophy. In Male N171-82Q HD mice, SRT2104 (diet containing 0.5% SRT2104) effectively penetrates the blood-brain barrier, attenuates brain atrophy, improves motor function, and extends survival.