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发布者：信康 浏览次数：
产品名称:N/ACAS:1374601-40-7别名：英文名：BRD4770
- 储存条件 2-8°C
- 溶解度 DMSO: soluble5mg/mL, clear (warmed)
- 颜色white to beige
- 生物活性BRD4770是一种histone methyltransferase G9a抑制剂，其IC50为6.3 μM，并且会诱导细胞死亡。
- 体外研究BRD4770 reduces cellular levels of di- and trimethylated H3K9 via inhibition of G9a, induces senescence, and inhibits both anchorage-dependent and -independent proliferation in the pancreatic cancer cell line PANC-1. The combination of gossypol and BRD4770 increases LC3-II levels and the autophagosome number, and thus acts in synergy to induce cell death in PANC-1 cells.
