ML324
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产品名称:ML324CAS:1222800-79-4别名：N-(3-(二甲氨基)丙基)-4-(8-羟基喹啉-6-基)苯甲酰胺英文名：ML234
- 储存条件 2-8°C
- 溶解度 DMSO: soluble10mg/mL, clear
- 颜色white to light brown
- 生物活性ML324是一种选择性的jumonji histone demethylase (JMJD2)抑制剂， 其对JMJD2E的IC50为920 nM。
- 体外研究ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection by inhibiting viral IE gene expression.
- 体内研究In a mouse ganglia explant model of latently infected mice, ML324 suppresses the formation of HSV plaques, and blocks HSV-1 reactivation.
