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产品名称:N/ACAS:919973-83-4别名：4-溴-N-(2,3-二氢-6-甲氧基-1,3-二甲基-2-氧代-1H-苯并咪唑-5-基)-2-甲基苯磺酰胺英文名：OF-1
- 储存条件 2-8°C
- 溶解度 DMSO: soluble5mg/mL, clear (warmed)
- 颜色white to beige
- 生物活性OF-1是一种有效的 BRPF1B和BRPF2 bromodomain抑制剂，Kd分别为100 nM 和 500 nM。
- 体外研究As a chemical probe for BRPF bromodomains, OF-1 increases thermal stability in the cellular thermal shift assay of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. In addition, OF-1 shows modest general cytotoxicity.
