SB-505124
发布者：信康 浏览次数：
产品名称:SB-505124CAS:694433-59-5别名：2-[4-(1,3-苯并二氧杂环戊烷-5-基)-2-(1,1-二甲基乙基)-1H-咪唑-5-基]-6-甲基-吡啶;2-[4-(1,3-苯并二恶茂-5-基)-2-(叔丁基)-1H-咪唑-5-基]-6-甲基吡啶;SB505124;SB505124;SB-505124,一种选择性TGFΒ受体ALK4和ALK5抑制剂英文名：2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride
- 密度 1.202
- 储存条件 2-8°C
- 溶解度 DMSO: >10mg/mL
- 颜色yellow
- 用途 SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptor ALK5 and as well as being a selective inhibitor of ALK4 but with less potency. SB-505124 blocks TGF-β鈥搃nduced apoptosis of FaO cells and NRP 154 cells in a concentration-dependent manner. SB-505124 has been shown to suppress the migration and invasion of breast cancer MCF-7-M5 cells.
