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发布者：信康 浏览次数：
产品名称:N/ACAS:1082949-68-5别名：LY-2584702对甲苯磺酸盐英文名：LY-2584702 (tosylate salt)
[] - 生物活性LY2584702 Tosylate是一种选择性的，ATP竞争性p70S6K抑制剂，IC50为 4 nM。Phase 1。
- 体外研究In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus.
- 体内研究LY2584702 (12.5 mg/kg BID, demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models.
