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发布者：信康 浏览次数：
产品名称:N/ACAS:955977-50-1别名：6-[[4-(环丙基甲基)-1-哌嗪基]甲基]-2-(5-氟-1H-吲哚-4-基)-4-(4-吗啉基)噻吩并[3,2-D]嘧啶英文名：PI-3065
[] - 生物活性PI-3065是一种选择性p110δ抑制剂，IC50为15 nM,选择性比其他PI3K家族成员高出70多倍。
- 体外研究PI-3065 shows no inhibition on the growth of 4T1 cells, which do not expressing detectable levels of p110δ.
- 体内研究In mouse model, PI-3065 (75 mg/kg, p.o.) also suppresses 4T1 tumor growth and metastasis via inactivation of p110δ. In the LSL.KrasG12D/+; p53R172H/+; PdxCretg/+ (or KPC) model of pancreatic ductal adenocarcinoma, PI-3065 prolongs survival and reduces the incidence of macroscopic metastases and other disease-associated pathologies.
