4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
发布者：信康 浏览次数：
产品名称:4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONECAS:327036-89-5别名：4-苄基-2-甲基-1,2,4-噻二唑烷-3,5-二酮;4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮;TDZD-8;TDZD8;TDZD8;NP01139;4-苯甲基-2-甲基-1,2,4-噻二唑烷-3,5-二酮100MG英文名：4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
- 熔点 63-64.4 °C
- 储存条件 2-8°C
- 溶解度 DMSO: 18 mg/mL
- 形态needles
- 颜色white
- 用途 Glycogen Synthase Kinase-3脽 is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3脽 ( IC50 =2nM). Binds to the active site of GSK-3脽. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM).
