1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲

发布者：信康浏览次数：

产品名称:1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲

CAS:792173-99-0

别名：1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲;N-(2-甲基-6-苯并恶唑基)-N'-1,5-二氮杂萘-4-基脲;N-(2-METHYL-6-BENZOXAZOLYL)-N'-1,5-NAPHTHYRIDIN-4-YL;1-(2-METHYL-1,3-BENZOXAZOL-6-YL)-3-(1,5-NAPHTHYRIDIN-4-YL)UREA

英文名：N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA

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生物活性SB-334867 是一种选择性 orexin-1 (OX1) receptor 拮抗剂。
体外研究In CHO-OX1 cells, SB-334867 inhibits the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses with pKB of 7.27 and 7.23 respectively, without effect on the UTP (3 microM)-induced calcium response.
体内研究In both male and female rats, SB-334867 (30 mg/kg, i.p.) significantly reduces natural and orexin-A-induced food intake. SB-334867 (2 mg/kg, i.v.) blocks the effects of antipsychotic drugs on dopamine neuronal activity in rats. SB-334867 also inhibits the development of morphine analgesic tolerance in rats.