T0070907
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产品名称:T0070907CAS:313516-66-4别名：2-氯-5-硝基-N-4-吡啶基苯甲酰胺;苯甲酰胺,2-氯-5-硝基-N-4-吡啶基-;2-氯-5-硝基-N-4-吡啶苯甲酰胺;2-氯-5-硝基-N-(吡啶-4-基)苯甲酰胺英文名：T0070907
- 密度 1.498
- 储存条件 Store at RT
- 溶解度 DMSO: >10mg/mL
- 颜色white
- 水溶解性 Soluble in DMSO at 10mg/ml. Insoluble in water.
- 敏感性 Light Sensitive
- 用途 A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 碌M and 1.8 碌M, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain.
