SCR7
发布者：信康 浏览次数：
产品名称:SCR7CAS:1533426-72-0别名：2,3-二氢-5,6-二[(E)-(苯基亚甲基)氨基]-2-硫代-4(1H)-嘧啶酮英文名：SCR7
[] - 生物活性SCR7 是一种特异性 DNA Ligase IV 抑制剂，其阻断非同源性末端连接(NHEJ)。
- 体外研究SCR7 effectively inhibits the formation of multimers at 200 μM and above. SCR7 successfully inhibits cell proliferation of MCF7, A549, HeLa, T47D, A2780, HT1080, and Nalm6 with IC50 of 40, 34, 44, 8.5, 120, 10, and 50 μM, respectively. SCR7 suppresses the NHEJ repair of CRISPR-Cas9-induced DSBs.
- 体内研究SCR7 treatment (10 mg/kg, i.m.) significantly reduces breast adenocarcinoma-induced tumor, and exhibits 4-fold increase in lifespan compared with control group. However, in Swiss albino mice with Dalton’s lymphoma tumor model, SCR7 (20 mg/kg, i.p.) exhibits neither tumor regression nor increase in lifespan. In BALB/c mice, SCR7 (20 mg/kg, i.p.) significantly enhances the cytotoxic effects of radiation, etoposide and 3-Aminobenzamide on tumor derived from Dalton’s lymphoma (DLA) cells.
