BMH-21
发布者：信康 浏览次数：
产品名称:BMH-21CAS:896705-16-1别名：N-[2-(二甲基氨基)乙基]-12-氧代-12H-苯并[G]吡啶并[2,1-B]喹唑啉-4-甲酰胺英文名：BMH21
- 储存条件 2-8°C
- 溶解度 DMSO: soluble1mg/mL, clear (warmed)
- 颜色light yellow to dark yellow
- 生物活性BMH-21是一种DNA嵌入剂，与核糖体DNA结合，并抑制RNA polymerase I (Pol I)转录。
- 体外研究BMH-21 causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. In U2OS cancer cell line, BMH-21 results in degradation of RPA194 and translocation of NCL with IC50 of 0.05 μM and 0.07 μM, respectively. By causing nucleolar stress, BMH-21 also shows potent inhibition on cell viability.
- 体内研究BMH-21 reduces tumor growth in mouse xenografts.
