YK 4-279
发布者：信康 浏览次数：
产品名称:YK 4-279CAS:1037184-44-3别名：4,7-二氯-1,3-二氢-3-羟基-3-[2-(4-甲氧基苯基)-2-氧代乙基]-2H-吲哚-2-酮;YK-4-279;YK4-279英文名：YK-4-279
- 熔点 149-151℃
- 密度 1.456
- 储存条件 Store at -20° C.
- 生物活性YK-4-279是EWS-FLI1与RNA helicase A (RHA)结合的有效抑制剂。
- 体外研究YK-4-279 eliminates cyclin D levels by blocking the interaction of EWS-FLI1 with RHA in EWS-FLI1-containing TC32 cells. YK-4-279 also specifically inhibits ESFT cell growth and induces apoptosis. YK-4-279 also inhibits ERG and ETV1 biological activity in fusion-positive prostate cancer cells, and further decreases cell motility and invasion.
- 体内研究In vivo, YK-4-279 (1.5 mg/dose i.p.) inhibits the growth of ESFT xenograft tumors. In mouse model, YK-4-279 selectively prevents prostate cancer growth and metastasis in fusion-positive LNCaP-luc-M6 tumors.
